The World Health Organization (WHO) stepped up its war on “Big Tobacco” on Tuesday, calling for stiff regulation of electronic cigarettes as well as bans on indoor use, advertising and sales to minors. The treaty recommends price and tax measures to curb demand as well as bans on tobacco advertising and illicit trade in tobacco products. In the report, the WHO said there are 466 brands of e-cigarettes and the industry represents “an evolving frontier filled with promise and threat for tobacco control”.