Bio-Reference Laboratories (BRLI) spiked 42% out of the starting gate Thursday, then settled to a 20% gain — up 6.64 to 39.60. Miami-based Opko Health (OPK) agreed to buy the gene-sequencing diagnostics firm for $1.5 billion. The thinly traded Bio-Reference had been struggling to move decisively past a 33.39 cup-with-handle buy point since January. It then built a flat base with a 36.85 buy point.