Britain is ready for \”hard negotiation\” to ensure Pfizer sticks to specific promises on jobs and science under the U.S. drugmaker’s proposed takeover of AstraZeneca, its finance minister said. \”I think it would be extraordinary not to engage with AstraZeneca or Pfizer,\” George Osborne told BBC radio on Saturday. He stressed Britain was an open economy that had benefited \”enormously\” from past investment by foreign companies, such as Tata Motors and Nissan in the car industry, and AstraZeneca itself had grown by taking over foreign firms.